Hybrid Studies and Other Approaches to Generate Real World Evidence
Think real world evidence. Think hybrid studies.
Filling evidence gaps and generating RWE through hybrid approaches
The demand for more real world evidence (RWE) is growing among healthcare stakeholders: it drives an enhanced understanding of complex issues and more efficient use of resources. And yet RWE remains in short supply, not least due to the limitations inherent in traditional methods of data collection and analysis. Subsequently, a growing interest in hybrid approaches, which use electronic medical records (EMRs) and database analysis to fill the knowledge gap between clinical trials and practice, has emerged. The use of these methods and others, such as cluster clinical trials, roll-over registries, and registry-based prospective RCTs, are predicted to grow over time; and many stakeholders see this as a route to improved health outcomes and better, more cost-efficient use of scarce resources.
Real world evidence (RWE) studies serve many purposes and are creating new opportunities for evidence generation in drug development. The demand for RWE is growing and is unlikely to subside as healthcare decision makers become increasingly aware of what it offers. With the rise of electronic medical records (EMRs), new hybrid approaches are evolving to cross-link data and close knowledge gaps. The landscape for RWE studies will be changing dramatically over the next few years as EMRs become more accessible. There are numerous hybrid designs to generate RWE insights. This article explores some of these, with a focus on hybrid EMR and database studies.Download Now